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Related Experiment Video

Updated: Jul 5, 2026

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.

Published on: June 14, 2015

An Anisotropic and Stable-Conductance Patch for Mechanical-Electrical Coupling With Infarcted Myocardium.

Yimeng Li^1,2,3,4, Yuchen Miao⁵, Leqian Wei^1,2,3

¹Shanghai Frontiers Science Center of Advanced Textiles College of Lextiles Donghua University Shanghai China.

Exploration (Beijing, China)

|January 1, 2026

Summary

This study introduces a novel woven conductive patch for repairing heart tissue after infarction. The patch mimics natural heart structure, improving cardiac function and reducing inflammation.

Keywords:

anisotropic bionic hierarchical structure cardiac repair mechanical–electrical coupling stretchable

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Last Updated: Jul 5, 2026

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.

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Published on: June 14, 2015

Transplantation of a 3D Bioprinted Patch in a Murine Model of Myocardial Infarction

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Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts

Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts

Published on: July 18, 2025

Area of Science:

Biomaterials Science
Cardiovascular Engineering
Regenerative Medicine

Background:

Polymeric conductive patches aid myocardial repair by improving electrical conduction and mechanical support.
Restoring electrical conduction and cardiac function with stable, anisotropic cues in vivo remains challenging.

Purpose of the Study:

To develop a novel anisotropic conductive patch for infarcted myocardium repair.
To mimic the hierarchical structure of myocardial fibers for enhanced biocompatibility and function.

Main Methods:

A weaving-based processing method was used to create a striated polypyrrole conductive coating on oriented elastic fiber bundles.
The patch's mechanical and electrical properties were precisely controlled using woven molding.
In vivo efficacy was tested using a rat myocardial infarction (MI) model.

Main Results:

The patch demonstrated exceptional stretchability (>400% elongation), stable conductance (ΔR/R0 = 0.04 within 20% strain), and fatigue resistance.
Anisotropic mechanical-electrical coupling with infarcted myocardium was achieved, improving cardiac function and electrical activity long-term.
The patch inhibited myocardial inflammation and fibrosis while promoting angiogenesis.

Conclusions:

The developed anisotropic conductive patch shows promise for treating myocardial infarction.
Woven technology offers a viable approach for processing biomaterials with both rigid and elastic components for biomedical applications.