Intersection of Tyrosine Kinase Inhibition and Sepsis-Induced Cardiomyopathy
Hiroshi Abe1, Kiyoshi Takasu1, Kei Yamamoto2
1Department of Cardiology, Juntendo Daigaku Igakubu Fuzoku Urayasu Byoin, Urayasu, Chiba Prefecture, Japan.
Case Reports in Pathology
|January 1, 2026
Summary
Sepsis-induced cardiomyopathy (SIC) can be fatal, especially in patients with prior heart conditions or on tyrosine kinase inhibitors (TKIs). This case highlights how these factors worsen sepsis-related heart damage, leading to rapid decline.
Area of Science:
- Cardiology
- Oncology
- Pathology
Background:
- A 78-year-old male with a history of myocardial infarction and chronic myeloid leukemia on tyrosine kinase inhibitors (TKIs) presented with heart failure.
- The patient developed a urinary tract infection, progressing to sepsis.
Purpose of the Study:
- To detail a case of sepsis-induced cardiomyopathy (SIC) in a patient with complex comorbidities.
- To explore the potential impact of pre-existing conditions and TKI therapy on SIC pathogenesis.
Main Methods:
- Clinical case presentation and review.
- Autopsy findings including histopathological examination.
Main Results:
- The patient exhibited signs of SIC, including myocardial injury and hemodynamic instability, ultimately leading to death.
- Autopsy revealed neutrophil-dominant inflammation and endothelial damage consistent with SIC, potentially exacerbated by old myocardial infarction and TKI therapy.
Conclusions:
- SIC is multifactorial, with pre-existing myocardial infarction and TKI therapy potentially worsening its progression.
- This case emphasizes the need for integrated management strategies in complex patients and further research into SIC mechanisms.
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