Related Experiment Video
Updated: Jan 7, 2026

12:18
A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
7.9K
Disparity implications of machine-learning-based MTM eligibility criteria
Journal of the American Pharmacists Association : Japha
|January 1, 2026
Summary
Predictive algorithms for Medicare Medication Therapy Management (MTM) eligibility may worsen racial disparities. Machine learning models reproduced lower cost-based eligibility for Black and Hispanic beneficiaries, highlighting a need for equitable MTM access strategies.
Area of Science:
- Health Services Research
- Health Equity
- Health Informatics
Background:
- Medicare Medication Therapy Management (MTM) programs offer clinical and economic advantages.
- Racial/ethnic minority groups encounter barriers to MTM program enrollment.
- The Enhanced MTM demonstration allows flexible beneficiary identification, but concerns about algorithmic bias persist.
Purpose of the Study:
- To determine if health cost-based MTM eligibility varies by race/ethnicity.
- To evaluate if machine learning models replicate existing disparities in predicted MTM eligibility.
Main Methods:
- Analysis of 2019 Medicare administrative data for a 10% random sample of fee-for-service beneficiaries.
- Assessment of top-quartile medication and healthcare costs from Medicare and healthcare system perspectives.
- Application of six machine learning algorithms to predict eligibility and assess racial/ethnic disparities.
Main Results:
- Black and Hispanic beneficiaries had significantly lower adjusted odds of top-quartile costs compared to non-Hispanic White beneficiaries.
- Machine learning models accurately reflected these disparities in predicted MTM eligibility.
- Observed disparities in medication and healthcare costs were consistently reproduced by predictive models.
Conclusions:
- Cost-based MTM eligibility determined by predictive algorithms may perpetuate racial/ethnic disparities in program access.
- Further research is needed to develop strategies for mitigating bias in MTM eligibility determination.
- Ensuring equitable access to MTM services requires addressing algorithmic biases.
More Related Videos
Related Concept Videos
Regression Toward the Mean
6.8K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.8K
Multiple Comparison Tests
4.4K
Multiple comparison test, abbreviated as MCT, is a post hoc analysis generally performed after comparing multiple samples with one or more tests. An MCT will help identify a significantly different sample among multiple samples or a factor among multiple factors.
It would be easy to compare two samples using a significance alpha level of 0.05. In other words, there is only one sample pair to be compared. However, it would be difficult to identify a significantly different sample if the number...
It would be easy to compare two samples using a significance alpha level of 0.05. In other words, there is only one sample pair to be compared. However, it would be difficult to identify a significantly different sample if the number...
4.4K
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving
255
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
255
Therapeutic Drug Monitoring: Affecting Factors
170
Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
170

