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Related Experiment Video

Updated: Jan 7, 2026

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

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DISTRIBUTED DELAY STABILIZES BISTABLE GENETIC NETWORKS.

Sean Campbell¹, Courtney C White¹, Amanda M Alexander^1,2

¹Department of Mathematics, University of Houston, Houston, Texas, USA.

|January 2, 2026

Summary

This summary is machine-generated.

Increasing noise in protein production delays stabilizes biological switches in genetic circuits. This finding enhances understanding of biological systems and aids synthetic biology design.

Keywords:

bistability delay stochastic simulation algorithm distributed delay genetic regulatory network stabilization of metastable states switching between delay distributions

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Published on: July 6, 2021

Area of Science:

Systems Biology
Synthetic Biology
Biophysics

Background:

Genetic regulatory networks (GRNs) exhibit inherent delays due to complex protein production processes.
These delays are often distributed (random) due to inherent noise in molecular events like transcription and translation.

Purpose of the Study:

To investigate the impact of distributed delays on the dynamics of bistable genetic circuits.
To understand how noise in protein production affects the stability of biological switches.

Main Methods:

Simulation of stochastic hybrid models with a switching-rate parameter.
Generalization and analysis of the three-states model for bistability.

Main Results:

Increased noise in the delay distribution significantly stabilizes metastable states in bistable genetic circuits.
Mean residence times in metastable states are dramatically increased with higher noise levels.

Conclusions:

Distributed delays and their associated noise play a crucial role in stabilizing biological switches.
Understanding these stabilization mechanisms can inform the design of robust synthetic genetic circuits.