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Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

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Targeted Radionuclide Detection of Malignant Tumors Using Affibody.

O D Bragina^1,2, A A Nesynov¹, E Yu Sitnikova³

¹Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, 634009 Russia.

|January 2, 2026

Summary

Affibody molecules show promise for in vivo tumor imaging and diagnostics. Clinical trials indicate radiopharmaceuticals are safe and effective for assessing cancer prevalence and HER2/neu status.

Keywords:

Malignant tumors affibodies alternative scaffold proteins targeted radionuclide diagnostics theranostics

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Published on: October 4, 2024

Area of Science:

Biotechnology
Clinical Medicine
Molecular Imaging

Background:

Affibody molecules offer high affinity and specificity for molecular targets.
Potential applications span biotechnology and clinical medicine.
In vivo visualization of malignant tumors is a key area of interest.

Purpose of the Study:

To review the applications of affibody molecules in biotechnology and medicine.
To highlight their role in in vivo tumor visualization.
To discuss preclinical and clinical studies of affibody conjugates for tumor imaging.

Main Methods:

Review of preclinical and clinical studies.
Examination of affibody conjugates with radioisotopes.
Analysis of targeted radionuclide tumor imaging.

Main Results:

Affibody conjugates are effective for in vivo tumor imaging.
Radiopharmaceuticals demonstrate good tolerability and efficacy in clinical trials.
Successful assessment of tumor process prevalence and HER2/neu status in breast cancer patients.

Conclusions:

Affibody molecules are valuable tools for molecular imaging and diagnostics.
Further research is supported by positive clinical trial outcomes.
These molecules aid in addressing challenges in cancer diagnosis and treatment.