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Analysis of Targeted Viral Protein Nanoparticles Delivered to HER2+ Tumors
Published on: June 18, 2013
Multifunctional theranostic nanoplatform based on HER2-specific liposomes loaded with IR783 for simultaneous PTT/PDT
E I Shramova1, A Yu Frolova2, E V Serova2
1Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, 16/10 Miklukho-Maklaya Street, Moscow, 117997, Russia; Federal State Budget Research Institution, Kirov Hematology and Blood Transfusion Research Institute Under the Federal Medicine and Biology Agency, Kirov, Russia.
Abstract:
We propose a new multifunctional nanoplatform for intravital optical bioimaging and combined photodynamic and photothermal therapy of HER2-positive cancers, using single-wavelength laser irradiation. The system consists of IR783-loaded liposomes functionalized with a HER2-targeting designed ankyrin repeat protein (DARPin_9-29), genetically fused to an albumin-binding domain (ABD). The bifunctional module DARP-ABD on the liposome surface provides HER2-specific tumor targeting with a high tumor-to-background ratio, enabling effective tumor bioimaging. IR783 encapsulated in liposomes retains its photothermal properties and ability to generate ROS when exposed to near-infrared irradiation. Administration of DARP-ABD-Lip(IR783) followed by laser irradiation resulted in significant tumor growth inhibition (TGI of 70.6% by day 10), which progressed to a remarkable 91.5% TGI by the end of the monitoring period.
