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Invasive Neuromodulation in Lennox-Gastaut Syndrome: A Systematic Review and Meta-Analysis
Helen Michaela de Oliveira1, Pandora Eloa Oliveira Fonseca2, Mariano Gallo Ruelas3
1Department of Medicine, Federal University of Mato Grosso, Sinop, Mato Grosso, Brazil.
Invasive neuromodulation, including Vagus Nerve Stimulation (VNS), Deep Brain Stimulation (DBS), and Responsive Neurostimulation (RNS), offers seizure reduction for Lennox-Gastaut Syndrome (LGS). DBS demonstrated the highest efficacy, though overall evidence quality is low, necessitating further trials.
Area of Science:
- Neurology
- Epileptology
- Neurosurgery
Background:
- Lennox-Gastaut Syndrome (LGS) is a severe, drug-resistant epileptic encephalopathy associated with significant morbidity and mortality.
- The high seizure burden in LGS necessitates exploring alternative therapeutic strategies beyond conventional anti-epileptic drugs.
- Invasive neuromodulation techniques are emerging as potential options for managing refractory LGS seizures.
Conclusions:
- Invasive neuromodulation, particularly DBS, can offer meaningful seizure reduction in Lennox-Gastaut Syndrome (LGS).
- However, the current evidence supporting these interventions is of very low certainty.
- Head-to-head randomized controlled trials are essential to confirm the relative effectiveness of these modalities and guide optimal treatment selection for LGS.
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