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Role of Hippocampus in Memory

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

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Related Experiment Video

Updated: Jan 7, 2026

Craniotomy Procedure for Visualizing Neuronal Activities in Hippocampus of Behaving Mice

Craniotomy Procedure for Visualizing Neuronal Activities in Hippocampus of Behaving Mice

Published on: July 24, 2021

Using Anatomy and Computational Theory to Inspire Neurophysiological Experiments on Information Processing Through

James J Knierim¹

¹Zanvyl Krieger Mind/Brain Institute, Solomon H. Snyder Department of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, Maryland, USA.

|January 3, 2026

Summary

This personal history details 27 years of research on the hippocampus, exploring how anatomical and computational literature guided discoveries. Key findings include differences in hippocampal subfield dynamics and entorhinal cortex inputs, crucial for spatial learning and memory.

Area of Science:

Neuroscience
Computational Neuroscience
Cognitive Neuroscience

Background:

Research influenced by anatomical and computational literature.

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Preparation of Acute Slices from Dorsal Hippocampus for Whole-Cell Recording and Neuronal Reconstruction in the Dentate Gyrus of Adult Mice

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Last Updated: Jan 7, 2026

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Personal history tracing lab discoveries over 27 years.

Motivated by understanding information processing in the hippocampal formation.