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Assessment of Child Anthropometry in a Large Epidemiologic Study
Published on: February 2, 2017
Kawasaki Disease in Infancy and Long-Term Body Mass Index Trajectories
1Professor, Department of Social Services and Healthcare Management, International University of Health and Welfare, Otawara, Tochigi, Japan.
Insights
A history of Kawasaki disease (KD) in infancy did not impact long-term body mass index (BMI) trajectories through early adolescence. This study found no association between childhood KD and later BMI patterns.
Area of Science:
- Pediatrics
- Cardiovascular Health
- Growth and Development
Background:
- Kawasaki disease (KD) is linked to long-term cardiovascular risks, prompting concerns about potential future obesity.
- Limited longitudinal data exist on body mass index (BMI) trajectories in children with a history of KD.
- Understanding these trajectories is crucial for assessing long-term health outcomes post-KD.
Purpose of the Study:
- To investigate the long-term body mass index (BMI) z-score trajectories in children with a history of Kawasaki disease (KD) from infancy to early adolescence.
- To determine if a history of KD influences the patterns of BMI changes over time.
- To provide insights into the cardiovascular health risks associated with KD by examining BMI development.
Main Methods:
- A secondary analysis was performed on a large, nationwide Japanese birth cohort of 19,642 children followed for 13 years.
- Exposure was defined as parent-reported hospitalization for Kawasaki disease (KD) between 6 and 18 months of age.
- Group-based multivariate trajectory modeling was used to identify distinct BMI z-score trajectory groups.
Main Results:
- Three distinct BMI z-score trajectories were identified: "Stable," "High-Decreasing," and "Low-Increasing."
- Multivariable adjustment revealed no significant association between a history of Kawasaki disease (KD) and membership in any of these BMI trajectory groups for both males and females.
- Infancy KD history did not predict different long-term BMI patterns.
Conclusions:
- A history of Kawasaki disease (KD) in infancy is not associated with altered long-term BMI trajectories up to early adolescence.
- These findings suggest that KD may not significantly impact overall BMI development during childhood and early adolescence.
- Further research may explore other long-term health outcomes related to cardiovascular health in KD survivors.
Introduction:
Kawasaki disease (KD) is associated with long-term cardiovascular risks, raising concerns about future obesity. However, robust longitudinal data on body mass index (BMI) are lacking. This study investigated long-term BMI trajectories from childhood to early adolescence in children with a history of KD.
Method:
We conducted a secondary analysis of 19,642 children from a nationwide Japanese birth cohort, followed for 13 years. The exposure was parent-reported hospitalization for KD between 6 and 18 months of age. The outcome was membership in distinct BMI z-score trajectory groups identified using group-based multivariate trajectory modeling.
Results:
Three distinct BMI z-score trajectories were identified ("Stable," "High-Decreasing," and "Low-Increasing"). After multivariable adjustment, a history of KD was not associated with membership in any trajectory group for either males or females.
Conclusions:
A history of KD in infancy was not associated with alterations in long-term BMI trajectories through early adolescence.
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