Related Experiment Video
Updated: Jan 7, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
Stability analysis of a time-delayed SIQR epidemic model with nonlinear transmission and control parameters
Kaijiao Huang1, Lifei Wang2, Faisal Mehmood1
1School of Mathematical Sciences & Center for Applied Mathematics of Guangxi, Guangxi Minzu University, Nanning, 530006, China; Guangxi Colleges & Universities Engineering Research Center, Guangxi Minzu University, Nanning, 530006, PR China.
None:
We introduce an SIQR epidemic model that integrates nonlinear transmission and two discrete time delays corresponding to incubation and treatment durations. The model seeks to encapsulate essential dynamical characteristics of epidemic advancement while being suitable for thorough stability examination. The local asymptotic stability of the disease-free and endemic equilibria is examined by Lyapunov-Krasovskii functionals and delay-dependent linear matrix inequalities (LMIs), which mitigate conservatism in the established stability constraints compared to time-invariant criteria. In the absence of delays, we obtain the classical Routh-Hurwitz criteria for local stability, and for positive delays, we formulate characteristic equations whose roots are examined to identify Hopf bifurcations. Transversality requirements are checked to ensure the presence of Hopf bifurcations and to determine key delay thresholds beyond which persistent oscillations form. We propose a delay-dependent feedback control rule that adaptively modifies transmission and quarantine rates; necessary conditions for stability under this control are provided in LMI form and converted into explicit, interpretable constraints on permissible delays and minimum control intensity. The model is augmented to incorporate basic demographic turnover and multi-stage infection delays to provide subgroup-specific treatment representations. Numerical simulations and bifurcation diagrams demonstrate and validate the theoretical findings, indicating how augmented delays or intensified nonlinear transmission can alter stability thresholds and provoke recurring outbreaks. Our findings quantify (i) essential delay durations that undermine stability and (ii) the control effort necessary to reestablish equilibrium, results that can be articulated as definitive decision thresholds for conversion into policy-relevant outputs.
More Related Videos
07:41Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0
Published on: June 5, 2017
11:53Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers
Published on: July 21, 2017
Related Concept Videos
Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model
When a drug is administered through a constant intravenous infusion and eliminated via nonlinear pharmacokinetics, it follows zero-order input. For example, oral drugs undergo first-order absorption upon administration and are eliminated through nonlinear pharmacokinetics.
In the case of subcutaneously administered drugs,...
Linear Approximation in Time Domain
For a simple pendulum with a mass evenly distributed along its length and the center of mass located at half the pendulum's length,...
Linear time-invariant Systems
The input-output behavior of an LTI system can be fully defined by its response to an impulsive excitation at its input. Once this impulse response is known, the system's reaction to any other input can be...
BIBO stability of continuous and discrete -time systems
To determine the BIBO stability, the convolution integral is utilized when a bounded continuous-time input is applied to a Linear Time-Invariant (LTI) system....
Stability
The stability of an LTI system is determined by the roots of its characteristic equation, known as poles. A system is stable if it produces a bounded...
Transmission-Line Differential Equations
Line Section Model
A circuit representing a line section of length Δx helps in understanding the transmission line parameters. The voltage V(x) and current i(x) are measured from...