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SGLT-2 inhibition in pediatric CKD: advances, challenges, and opportunities

Franz Schaefer1

  • 1Division of Pediatric Nephrology, Department of Pediatrics I, Faculty of Medicine, University of Heidelberg, Heidelberg, Germany.

Kidney International
|January 4, 2026
PubMed

Insights

Sodium-glucose cotransporter-2 inhibitors show promise for children with chronic kidney disease (CKD). Pediatric trials are needed to address unique challenges and ensure safe, effective treatments for pediatric CKD.

Area of Science:

  • Pediatric Nephrology
  • Pharmacology
  • Clinical Trials

Background:

  • Sodium-glucose cotransporter-2 (SGLT2) inhibitors demonstrate significant renal and cardiovascular benefits in adult chronic kidney disease (CKD) patients.
  • Pediatric studies for SGLT2 inhibitors are limited due to prior regulatory exclusions of this population.
  • Pediatric CKD presents distinct characteristics, including congenital anomalies and nonglomerular disorders, differing from adult disease progression.

Keywords:
SGLT2 inhibitorsdisease progressionpediatric CKDpharmacologic renoprotection

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