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Related Concept Videos

Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

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Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
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Parentral Nutrition: Centeral and Peripheral Parental Nutrition01:27

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Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
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CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
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Endocarditis I: Introduction01:25

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Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
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Increased Body Temperature01:25

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A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
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Acute Pyelonephritis I: Introduction01:27

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Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
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Types of Fever01:25

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Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:
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Related Experiment Video

Updated: Jan 7, 2026

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit
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Peripherally inserted central catheter line-induced fevers: a case report.

Catherine Van't Hoff1, Benjamin H L Harris1, Ahilan Kailaya-Vasan2

  • 1Cutrale Perioperative and Ageing Group, Department of Bioengineering, Imperial College London, London, UK.

Journal of Medical Case Reports
|January 4, 2026
PubMed
Summary
This summary is machine-generated.

Noninfectious fevers can occur in patients with peripherally inserted central catheter (PICC) lines. This case highlights a potential complication beyond infection, emphasizing the need for further investigation into underlying mechanisms.

Keywords:
Fever of unknown originPICC line

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Area of Science:

  • Medical Devices
  • Clinical Case Reports
  • Infectious Disease

Background:

  • Peripherally inserted central catheter (PICC) lines are widely used in modern medicine.
  • While generally safe, complications like pain, bleeding, and blockage can occur.
  • Serious risks include line-associated sepsis.

Purpose of the Study:

  • To report a case of recurrent fever in a patient with sterile PICC lines.
  • To explore potential noninfectious causes of fever in PICC line patients.

Main Methods:

  • Case presentation of a 32-year-old Indian woman.
  • Clinical evaluation of recurrent fever in the context of indwelling PICC lines.
  • Exclusion of infectious etiologies.

Main Results:

  • The patient experienced recurrent fevers.
  • PICC lines were confirmed to be sterile, ruling out infection as the cause.
  • The underlying mechanism for the noninfectious fever remains uncertain.

Conclusions:

  • Noninfectious fevers are a potential complication associated with PICC lines.
  • The exact mechanisms driving these fevers require further research.
  • This case underscores the importance of considering noninfectious etiologies in febrile patients with PICC lines.