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Polydatin Protects Against the Formation of PPE-Induced Abdominal Aortic Aneurysms in Mice by Activating Nuclear

Zikang Liu1, Jinyi Zhu2, Qian Zhou1

  • 1Department of Cardiothoracic Surgery, Jingzhou Central Hospital Affiliated to Yangtze University, Jingzhou City, Hubei Province, China.

Drug Development Research
|January 5, 2026
PubMed

Insights

Polydatin (PLD) activates the NRF2 pathway, offering a potential therapeutic strategy against abdominal aortic aneurysm (AAA) rupture. This study shows PLD attenuates AAA by reducing inflammation and cell death.

Area of Science:

  • Cardiovascular Research
  • Molecular Biology
  • Pharmacology

Background:

  • Abdominal aortic aneurysm (AAA) rupture is a fatal cardiovascular event with limited therapeutic options.
  • Polydatin (PLD), known for anti-inflammatory properties, has not been studied for its role in AAA.
  • There is an urgent need for novel therapeutic strategies to slow AAA progression.

Purpose of the Study:

  • To investigate the regulatory role of polydatin (PLD) in abdominal aortic aneurysm (AAA) formation.
  • To evaluate the effect of PLD on NRF2 signaling in a mouse model of AAA.
  • To determine if PLD can attenuate AAA progression by modulating cellular and inflammatory responses.

Main Methods:

  • A porcine pancreatic elastase (PPE) infusion-induced AAA mouse model was utilized.
  • PLD's effects on NRF2 signaling were assessed using Western blot (WB), immunohistochemistry (IHC), immunofluorescence (IF), flow cytometry (FC), and RT-qPCR.
  • Key cellular processes including smooth muscle cell (SMC) phenotypic transformation and apoptosis were analyzed.

Main Results:

  • Polydatin (PLD) robustly activated the NRF2 signaling pathway in the AAA model.
  • PLD significantly attenuated AAA formation.
  • PLD curbed SMC phenotypic transformation and apoptosis and suppressed macrophage-mediated inflammation.

Conclusions:

  • Polydatin (PLD) demonstrates therapeutic potential for abdominal aortic aneurysm (AAA).
  • Activation of the NRF2 pathway by PLD is a key mechanism in attenuating AAA.
  • PLD offers a promising strategy to mitigate AAA progression by targeting cellular dysfunction and inflammation.
Keywords:
abdominal aortic aneurysmapoptosisnuclear factor erythroid 2‐related factor 2polydatin

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