A Topical Cosmeceutical Approach to Submental Fullness in Indian Women: 12-Week Prospective Study

Area of Science:

• Dermatology
• Cosmeceuticals
• Aesthetic Medicine

Background:

• Submental fullness, commonly known as a "double chin," is a prevalent aesthetic concern for Indian women.
• Currently, no topical cosmeceutical has been systematically evaluated for treating submental fullness in this demographic.

Purpose of the Study:

• To evaluate the efficacy of a novel multi-active topical serum containing Dimethylaminoethanol (DMAE) and retinol.
• The primary objective was to assess its effectiveness in reducing submental fullness among Indian women.

Main Methods:

• An open-label, single-center study was conducted over 12 weeks with 16 participants (ages 18-60) experiencing mild-to-moderate submental fullness.
• Participants applied the DMAE and retinol serum nightly to the submental area.
• Standardized photographs were assessed at baseline and week 12 by independent dermatologists using the Clinician-Reported Submental Fat Rating Scale, with body weight monitored.

Main Results:

• All 13 participants who completed the study demonstrated visible improvements in submental contour.
• Dermatologist assessments revealed statistically significant improvements in submental fullness across all views (p < 0.05).
• Improvements were observed irrespective of body weight fluctuations, and no adverse events were reported.

Conclusions:

• This preliminary research indicates that a topical serum containing DMAE and retinol can effectively improve submental fullness in Indian women within 12 weeks.
• The serum presents a potential non-invasive alternative to surgical or procedural interventions for submental fat reduction.
• Further validation through larger randomized controlled trials with objective volumetric measurements is recommended.