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Chlamydia Abortus-Induced Pneumonia with Psychiatric Symptoms and Pneumomediastinum: A Case Report
Bing Ding1, Zengkai Xu1, Youtang Li1
1Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, 364000, People's Republic of China.
Background:
Chlamydia abortus is a zoonotic pathogen that commonly causes abortion, pelvic inflammatory disease, or septicemia during pregnancy in humans. It can occasionally lead to pneumonia.
Case Presentation:
We report a 35-year-old male with pneumonia complicated by psychiatric symptoms and pneumomediastinum. Initial treatment with cefotaxime and piperacillin-tazobactam failed. On admission, chest CT revealed bilateral pulmonary inflammation, pneumomediastinum, and cervical subcutaneous emphysema. Bronchoalveolar lavage fluid underwent Targeted Next-Generation Sequencing, identifying Chlamydia abortus. Treatment with doxycycline and moxifloxacin led to resolution of fever, psychiatric symptoms, and pulmonary lesions. The patient continued oral doxycycline post-discharge, and follow-up CT showed near-complete recovery.
Conclusion:
Chlamydia abortus infection can cause pneumonia with psychiatric symptoms, pneumomediastinum, and cervical emphysema-complications not previously reported. Targeted Next-Generation Sequencing (Targeted NGS) plays a crucial role in the early and precise detection of Chlamydia abortus, improving diagnostic accuracy and treatment timeliness. Doxycycline is effective in the treatment of Chlamydia abortus infection and contributed to the patient's recovery.
Insights
Chlamydia abortus, a zoonotic pathogen, can cause severe pneumonia with unusual complications like psychiatric symptoms and pneumomediastinum in humans. Early detection via Targeted Next-Generation Sequencing and treatment with doxycycline are crucial for recovery.
Area of Science:
- Infectious Diseases
- Pulmonology
- Genomics
Background:
- Chlamydia abortus is a zoonotic pathogen known to cause pregnancy complications and occasionally pneumonia in humans.
- This bacterium can lead to serious conditions such as abortion, pelvic inflammatory disease, and septicemia.
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