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Updated: Jan 7, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

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Minimal Change Disease with Progression to Focal Segmental Glomerulosclerosis: Support for an Immune-Mediated Disease

Ritika Muthyala1, Abhinav R Thummala2, Michael Neinast3

  • 1Texas College of Osteopathic Medicine University of North Texas Health Science Center.

Journal of Brown Hospital Medicine
|January 5, 2026
PubMed

Insights

Minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) may represent a spectrum of podocyte injury. Early plasmapheresis (PLEX) may be crucial for nephrotic syndrome with IgG deposits.

Area of Science:

  • Nephrology
  • Pathology

Background:

  • Minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) are leading causes of nephrotic syndrome in adults.
  • Podocyte injury is central to the pathogenesis of both conditions.
Keywords:
FSGSMCDfocal segmental glomerulosclerosisminimal change diseaseplasmapheresis

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