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Updated: Jan 7, 2026

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

Solid-State Nanopore-Based Cell Analysis.

Kewen Song¹, Ruidong Gao¹, Xinyi Pan¹

¹Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, China.

Analytical Chemistry

|January 5, 2026

Summary

This summary is machine-generated.

Solid-state nanopore technology offers label-free, real-time cell analysis for biological insights. This review details advances in single nanopore, nanopipette, and array systems for cell monitoring and disease diagnosis.

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Last Updated: Jan 7, 2026

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

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Published on: October 31, 2013

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

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Monitoring Protein Adsorption with Solid-state Nanopores

Monitoring Protein Adsorption with Solid-state Nanopores

Published on: December 2, 2011

Area of Science:

Biotechnology
Nanotechnology
Cell Biology

Background:

Accurate cell and intracellular molecule monitoring is vital for understanding biological processes and diagnosing diseases.
Nanopore sensing technology, known for label-free, real-time analysis, is increasingly used in cell analysis.
Solid-state nanopores offer advantages over biological nanopores, including mechanical stability and tunable dimensions.

Purpose of the Study:

To review the latest advancements in solid-state nanopore technology for cell analysis.
To categorize and discuss different types of solid-state nanopore systems used in cell analysis.
To identify challenges and future opportunities for solid-state nanopore applications in cell analysis.

Main Methods:

Categorization of solid-state nanopores into single nanopore, nanopipette, and nanopore array systems.
Detailed discussion of method design, working principles, and technical characteristics for each type.
Analysis of specific applications in cell analysis for each categorized system.

Main Results:

Solid-state nanopores demonstrate significant potential for label-free, real-time cell analysis.
Single nanopores, nanopipettes, and nanopore arrays have been developed with specific designs and applications.
The review highlights the progress and capabilities of these systems in various cell analysis contexts.

Conclusions:

Solid-state nanopore technology is a promising tool for advancing cell analysis and disease diagnosis.
Further research is needed to address key challenges for practical translation of this technology.
Future development opportunities lie in refining existing systems and exploring novel applications in cell biology.