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Related Experiment Video

Updated: Jan 7, 2026

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model
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Published on: April 18, 2025

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Optimized Electrical Stimulation Using a Spray-Printed Conductive Electroceutical Patch for Accelerated Wound Healing

Jung Hyun Kim1, Soo A Kim2, Seung Hyun Lee1

  • 1Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University (SKKU), Suwon, Republic of Korea.

Advanced Healthcare Materials
|January 5, 2026
PubMed
Summary

Electrical stimulation (ES) optimizes wound healing in diabetic mice by reducing inflammation and promoting tissue regeneration. A novel spray-printed electroceutical patch delivers these optimized ES parameters, offering a promising therapeutic platform for chronic wounds.

Keywords:
chronic wound healingconductive inkelectroceuticalsimmunomodulationsoft electronics

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Wound Healing Research

Background:

  • Diabetic wound healing is impaired by chronic inflammation and vascular dysfunction.
  • Current electroceutical therapies face challenges with parameter optimization and device limitations.
  • Modulating macrophage and cellular activity is crucial for transitioning wounds to a regenerative state.

Purpose of the Study:

  • To identify optimal electrical stimulation (ES) parameters for chronic wound treatment.
  • To develop a novel electroceutical patch for effective ES delivery.
  • To evaluate the therapeutic potential of optimized ES via the patch in a diabetic wound model.

Main Methods:

  • Screening of key ES parameters to attenuate inflammation and promote regeneration.
  • Fabrication of a spray-printed conductive ink electroceutical patch (SCOPE) using PVA and LM.
  • In vivo assessment of the SCOPE patch in a diabetic mouse wound model.

Main Results:

  • Optimized ES parameters were identified to reduce inflammation and enhance regenerative processes.
  • The SCOPE patch demonstrated stable and conductive ES delivery at dynamic wound sites.
  • Application of the SCOPE patch suppressed inflammation and improved re-epithelialization and neovascularization in diabetic mouse wounds.

Conclusions:

  • Optimized ES conditions effectively modulate immune responses for chronic wound healing.
  • The SCOPE patch represents a viable therapeutic platform for delivering optimized ES.
  • This approach shows significant potential for treating chronic inflammatory conditions and promoting tissue regeneration.