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Parabens potential as polymer additives in supersaturable formulations
Maryam Maghsoodi1, Mehdi Ezzati Nahand1, Ali Nokhodchi2
1School of Pharmacy and Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Pharmaceutical Development and Technology
|January 5, 2026
Summary
Methylparaben and propylparaben enhance Eudragit S100
Area of Science:
- Pharmaceutical Science
- Drug Delivery Systems
- Polymer Science
Background:
- Supersaturation is crucial for enhancing drug solubility and bioavailability.
- Eudragit S100 (EU) is a polymer used to stabilize drug supersaturation.
- Additives can potentially improve the performance of drug delivery systems.
Purpose of the Study:
- To evaluate methylparaben and propylparaben as additives for Eudragit S100 (EU).
- To assess their effect on stabilizing dipyridamole (DP) supersaturation.
- To understand the mechanism of paraben influence on EU-mediated DP supersaturation stabilization.
Main Methods:
- Comparison of EU/paraben binary compositions with physical mixtures.
- Assessment of dipyridamole (DP) supersaturation stabilization.
- Fourier Transform Infrared (FT-IR) spectroscopy to study EU-paraben interactions.
Main Results:
- EU/paraben binary compositions significantly improved DP supersaturation stabilization compared to EU alone.
- Physical mixtures of EU and parabens did not show enhanced DP supersaturation stabilization.
- Parabens enhanced the dissolution rate of EU, likely due to intermolecular interactions.
Conclusions:
- Parabens act as effective additives to enhance the dissolution rate of Eudragit S100 (EU).
- This enhancement leads to improved stabilization of dipyridamole (DP) supersaturation.
- The findings offer a strategy for improving drug supersaturation maintenance using polymer-based systems with additives.
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