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Related Experiment Video

Updated: Jan 13, 2026

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
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Mindfulness-Oriented Recovery Enhancement for Cancer Pain Relief: Pilot Randomized Controlled Trial.

Karolina L Bryl1, Adam W Hanley2, Raymond E Baser3

  • 1Integrative Medicine and Wellness Service (K.L.B., K.D., M.D., Q.L., B.S., J.J.M.), Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Journal of Pain and Symptom Management
|January 6, 2026
PubMed
Summary
This summary is machine-generated.

Mindfulness-Oriented Recovery Enhancement (MORE) is a feasible and acceptable intervention for cancer survivors experiencing chronic pain. This pilot study suggests MORE may effectively reduce pain interference and severity, offering a new treatment avenue.

Keywords:
Cancer survivorsMindfulness-Oriented Recovery Enhancementmindfulnesspain

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Area of Science:

  • Oncology
  • Pain Management
  • Psychosocial Interventions

Background:

  • Chronic pain is prevalent and undertreated in cancer survivors.
  • Current treatments have limitations, necessitating novel interventions.
  • Mindfulness-Oriented Recovery Enhancement (MORE) shows promise but hasn't been studied in this population.

Purpose of the Study:

  • Evaluate the feasibility and acceptability of MORE in cancer survivors.
  • Explore the preliminary efficacy of MORE on pain interference and severity.
  • Assess different formats of MORE for potential dose-response effects.

Main Methods:

  • Pilot randomized controlled trial with 60 cancer survivors with moderate-to-severe pain.
  • Randomization to three MORE formats (16, 8, 2 hours) or waitlist control.
  • Feasibility assessed by enrollment/completion rates; acceptability by adherence/satisfaction; efficacy by pain measures.

Main Results:

  • High feasibility (70.6% enrollment, 91% completion) and acceptability (high adherence, satisfaction).
  • All MORE formats showed significant reductions in pain interference and severity compared to baseline.
  • A dose-response effect was observed, with all formats demonstrating efficacy.

Conclusions:

  • MORE is a feasible and acceptable intervention for chronic pain in cancer survivors.
  • Preliminary evidence suggests MORE's efficacy in reducing pain interference and severity.
  • Further research is warranted to confirm these findings and optimize MORE delivery.