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Updated: Jun 10, 2026

Transcutaneous Microcirculatory Imaging in Preterm Neonates
Published on: December 31, 2015
Skin InteGrity in extreme preterms research NETwork (SIGNET) - improving skin care for the most immature infants
Deanne August1,2,3, Sabrina de Souza4, Vita Boyar5
1Neonatology, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia. Deanne.August@health.qld.gov.
Insights
Optimal skin care for extremely preterm infants is crucial for preventing infection and reducing complications. The Skin InteGrity in extreme preterms research NETwork (SIGNET) collaborative aims to improve evidence-based skin care practices for these vulnerable infants.
Area of Science:
- Neonatalogy
- Dermatology
- Evidence-based practice
Background:
- Increasing survival rates of extremely preterm infants (<28 weeks' gestation) present unique challenges in neonatal intensive care.
- Optimal skin care is vital for preventing infection, minimizing pain, and reducing fluid loss in vulnerable preterm infants.
- Current variations in care practices and lack of specific evidence impact infant outcomes, including morbidity and mortality.
Purpose of the Study:
- To review challenges in providing effective skin care for extremely preterm infants.
- To identify research priorities and benchmarking opportunities in neonatal skin care.
- To propose a collaborative framework for advancing evidence-based skin care practices.
Main Methods:
- Literature review and synthesis of current evidence on neonatal skin care.
- Identification of key challenges and gaps in existing research and clinical practice.
- Proposal of a collaborative network (SIGNET) to address identified needs.
Main Results:
- Significant gaps exist in high-quality, population-specific evidence for preterm infant skin care.
- Variability in care delivery impacts immediate survival and long-term outcomes.
- A collaborative approach is needed to standardize and improve skin care.
Conclusions:
- There is a critical need for evidence-based guidelines for skin care in extremely preterm infants.
- The Skin InteGrity in extreme preterms research NETwork (SIGNET) collaborative offers a framework for research, knowledge exchange, and tool development.
- Standardized, high-quality skin care is essential for improving outcomes in this vulnerable population.
Abstract:
Increased survival of preterm infants born <28 weeks' gestation brings new challenges for healthcare teams and families, particularly in the absence of high-quality, population-specific evidence to guide optimal skin care. Skin integrity is critical for preventing infection, reducing pain, and minimizing fluid loss. However, variations in care, delivery models, geographic settings, and clinician expertise continue to influence outcomes-impacting both immediate survival, long-term morbidity and mortality. This review outlines the key challenges associated with delivering safe and effective skin care for extremely preterm infants; identifies priority areas for research and benchmarking, and proposes a collaborative approach to address these gaps. The Skin InteGrity in extreme preterms research NETwork (SIGNET) collaborative seeks to align outcome measures, generate essential physiological data, promote knowledge exchange, and develop practical, evidence-based tools to support consistent, high-quality care for these uniquely vulnerable patients.
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