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Updated: Jan 13, 2026
08:46
Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
Published on: December 9, 2015
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Navigating the New Therapeutic Landscape: Innovative Strategies for Overcoming Resistance and Degeneration
Hyun-Jeong Ko1, Chang Hoon Lee2
1College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea.
Biomolecules & Therapeutics
|January 6, 2026
Summary
This special issue explores innovative therapeutic strategies for complex diseases. It covers advancements in oncology, degenerative diseases, and neuro-immune axis modulation for better patient outcomes.
Area of Science:
- Biomedical Science and Therapeutics
- Translational Medicine
- Disease Pathogenesis
Background:
- Therapeutic landscape evolution driven by technological and environmental changes.
- Shift from understanding pathogenesis to developing targeted therapies.
- 2026 Special Issue focuses on methodological innovations and advanced interventions.
Purpose of the Study:
- To present cutting-edge research on therapeutic interventions and methodological innovations.
- To explore strategies for overcoming therapeutic resistance in oncology.
- To investigate novel treatments for degenerative, metabolic, and neuro-immune diseases.
Main Methods:
- Investigating transglutaminase 2 (TG2)-mediated autophagy and ferroptosis.
- Advances in CAR-T cell engineering and AI integration with robotic surgery.
- Elucidating Wnt/β-catenin signaling, gene editing in iPSC-derived hepatic models, and kynurenine-aryl hydrocarbon receptor (AhR) axis modulation.
Main Results:
- Novel strategies to overcome therapeutic resistance in oncology.
- Insights into Wnt/β-catenin signaling in osteoporosis and knee osteoarthritis treatments.
- Understanding of drug-induced senescence and neuro-immune axis roles in Alzheimer's disease.
Conclusions:
- The issue provides groundbreaking insights into restoring biological homeostasis.
- Innovative strategies are presented for overcoming intractable diseases.
- Focus on precision medicine and advanced therapeutic interventions.
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