Related Experiment Video
Updated: Jan 13, 2026

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
Published on: May 18, 2022
Association between cardiovascular health and epigenetic aging: a twin study
Hui Cao1,2, Ziyun Jiang1,2, Weihua Cao1,2
1Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Objective:
To explore the association between life's essential 8 and epigenetic age based on twins population.
Methods:
This study included 1030 twins (515 pairs) for cross-sectional analysis and conducted cross-lagged analysis among 294 twins (147 pairs) who participated in both the baseline and follow-up surveys from the Chinese National Twin Registry. LE8 scores were obtained from measurements based on American Heart Association definitions. DNA methylation data were used to calculate epigenetic age metrics, including GrimAA, DamAA and DunedinPACE. Linear mixed-effect models were applied for cross-twin analyses and within-monozygotic-pair analyses.
Results:
In the cross-sectional analysis, higher LE8 score was associated with slower epigenetic aging (DunedinPACE and DamAA) in both across-twin analyses and within-monozygotic-pair analyses. In stratified analyses, the association between LE8 score and epigenetic age appeared more significant in males and in individuals aged 50 years older. The cross-lagged analysis further revealed significant temporal associations between LE8, health factor, and DunedinPACE.
Conclusion:
Higher LE8 scores were associated with a deceleration in biological aging.
Related Concept Videos
Gene-Environment Interactions
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
The Effect of Aging on Tissues
Pharmacodynamics in Geriatric Patients: Effects of Age
Epigenetic Regulation
Epigenetic Regulation
X-chromosome...

