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Antibiotic Dereplication Using the Antibiotic Resistance Platform
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Rethinking the unmet need for novel antibiotics.

Eric J Evans1,2, P Douglas Witt3, George G Zhanel4

  • 1Mossavar-Rahmani Center for Business and Government, Harvard Kennedy School, Cambridge, MA, USA. eevans@massmedangels.com.

The Journal of Antibiotics
|January 6, 2026
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Summary
This summary is machine-generated.

The biopharmaceutical industry underinvests in new antibiotics due to low profit potential. A new strategy focusing on pathogen-general potentiators could solve treatment failures and attract investment.

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmaceutical Sciences

Background:

  • The Antibiotic Resistance crisis is characterized by insufficient biopharmaceutical industry investment in novel antibiotics.
  • Limited profit potential is a major barrier to developing new antimicrobial drugs.

Purpose of the Study:

  • To propose a shift in focus for antibiotic development, moving from solely targeting highly drug-resistant pathogens to addressing empiric treatment failure.
  • To introduce a novel framework centered on developing pathogen-general potentiators to stimulate industry investment.

Main Methods:

  • Conceptual analysis and framework proposal for antibiotic discovery.
  • Redefining the primary problem in antibiotic development from infection mortality to treatment failure.

Main Results:

  • Empiric treatment failure represents a more significant problem than deaths from specific resistant pathogens.
  • Pathogen-general potentiators offer a viable solution to empiric treatment failure.
  • This approach presents a potential profit model attractive to the biopharmaceutical industry.

Conclusions:

  • Reframing the antibiotic resistance challenge towards empiric treatment failure is crucial.
  • Developing pathogen-general potentiators is a promising strategy to overcome industry underinvestment.
  • This novel framework could revitalize antibiotic discovery and development efforts.