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Programmable cell-cell adhesion in synthetic yeast communities for improved bioproduction.
Haohong Chen1,2,3,4,5, Huadong Peng1,2,3,4,6,7,8, Tom Ellis1,2,3,4
1Imperial College Centre for Synthetic Biology, Imperial College London, London, UK.
Nature Chemical Biology
|January 6, 2026
Summary
This study presents a new yeast synthetic biology toolkit for controlled cell-cell adhesion and cocultures. This system enhances bioproduction, offering a valuable resource for synthetic biology and biomanufacturing applications.
Area of Science:
- Synthetic biology
- Biotechnology
- Cellular engineering
Background:
- Multicellular systems require controlled cell-cell adhesion and metabolic interdependence for complex functions.
- Existing methods for engineering cell adhesion lack genetic specificity and control.
Purpose of the Study:
- To develop a yeast synthetic toolbox for modular cell-cell adhesion and cocultures.
- To establish genetically specific adhesion systems for enhanced bioproduction.
Main Methods:
- Created a model yeast strain (007Δ) by removing seven key flocculation and agglutination genes.
- Developed three distinct adhesion pair systems using yeast flocculation/agglutination proteins and yeast surface display.
- Quantitatively assessed adhesion specificity, strength, and pattern generation capabilities.
Main Results:
- Successfully engineered modular cell-cell adhesion systems in yeast.
- Demonstrated quantitative control over adhesion specificity and pattern formation.
- Achieved enhanced bioproduction of resveratrol using synthetic cocultures with synthetic adhesion.
Conclusions:
- The developed yeast synthetic toolbox enables precise control over cell-cell adhesion and coculture formation.
- This toolkit facilitates enhanced bioproduction of valuable compounds like resveratrol.
- The system is a promising resource for synthetic biology and biomanufacturing.
