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Chordae Rupture Alters Tricuspid Valve Leaflet Biomechanics.

Julia Clarin1, Keyvan A Khoiy2, Samuel D Salinas1

  • 1Department of Bioengineering, Northeastern University, Boston, MA, USA.

Cardiovascular Engineering and Technology
|January 6, 2026
PubMed
Summary

Tricuspid valve chordae tendineae rupture causes immediate hemodynamic changes and increased leaflet stretch, potentially leading to long-term valve remodeling. This study highlights the acute biomechanical impact of this often-overlooked valvular lesion.

Keywords:
Cardiac traumaChordae tendineae ruptureEx vivo porcine heart modelMechanical strainsPractice problemTricuspid valve

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Area of Science:

  • Cardiovascular Physiology
  • Biomedical Engineering
  • Cardiac Mechanics

Background:

  • Tricuspid valve chordae tendineae rupture is an underrecognized valvular lesion.
  • The prevalence of tricuspid valve chordae rupture may be higher than currently appreciated.
  • Understanding the acute biomechanical consequences of chordae rupture is crucial for predicting long-term remodeling.

Purpose of the Study:

  • To investigate the hemodynamic and biomechanical effects of tricuspid valve chordae tendineae rupture.
  • To elucidate how acute changes in the mechanical environment post-rupture influence tissue remodeling.
  • To quantify the immediate impact of chordae rupture on tricuspid valve leaflet dynamics.

Main Methods:

  • Ex vivo study utilizing porcine hearts.
  • Sonomicrometry techniques employed to measure leaflet deformation.
  • Chordae rupture induced by severing a chordae bundle to the septal leaflet.

Main Results:

  • Pulmonary artery pressure decreased by approximately 5 mmHg post-rupture, indicating immediate valvular regurgitation.
  • Mean maximum principal stretch of the septal leaflet increased by 12% following chordae rupture.
  • Acute alterations in the biomechanical environment of the tricuspid valve were observed.

Conclusions:

  • Chordae tendineae rupture acutely modifies the biomechanical environment of the tricuspid valve.
  • Immediate changes in leaflet stretch suggest a potential for chronic tissue remodeling.
  • The findings underscore the significance of tricuspid valve chordae integrity in maintaining valvular function.