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What’s new in transplantation in 2025?
1Centre hospitalier universitaire d’Orléans, service de néphrologie, Orléans, France
Nephrologie & Therapeutique
|January 6, 2026
Summary
Kidney transplantation is shifting to precision medicine. New biomarkers like donor-derived cell-free DNA and advanced diagnostics are improving rejection detection and monitoring for personalized patient care.
Area of Science:
- Nephrology
- Immunology
- Transplantation Medicine
Background:
- Kidney transplantation is evolving towards precision medicine.
- Advances in understanding rejection, diagnostics, and therapeutics are crucial.
Purpose of the Study:
- To review the latest advancements in kidney transplantation in 2025.
- To highlight the shift towards precision medicine in transplant care.
Main Methods:
- Review of recent studies and clinical findings.
- Focus on antibody-mediated rejection (ABMR) diagnostics and therapeutics.
- Inclusion of circulating biomarkers, imaging, and xenotransplantation.
Main Results:
- Microvascular inflammation is key in ABMR, regardless of DSA or C4d.
- Circulating biomarkers (dd-cfDNA, transcriptomics) aid rejection monitoring.
- New therapies (anti-CD38, IVIg) and agents (SGLT2 inhibitors) show promise.
- Quantitative imaging and xenotransplantation are advancing.
Conclusions:
- Precision medicine is transforming kidney transplantation.
- Individualized management is achieved through molecular, immunologic, and technological integration.
- The field is moving towards targeted restoration of immunity and graft protection.
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