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FLASH-therapy suitable single-pulse proton generation using TiH2 under nanosecond laser irradiation
Shotaro Matsui1, Takeshi Kanesue2, Shunsuke Ikeda2
1Research Center for Nuclear Physics, The University of Osaka, Suita, Osaka 567-0047, Japan.
The Review of Scientific Instruments
|January 6, 2026
Summary
Proton emission from titanium hydride targets using lasers shows consistent yields over 1000 shots, supporting their use in ultra-high-dose-rate FLASH-therapy studies.
Area of Science:
- Plasma Physics
- Materials Science
Background:
- Titanium hydride (TiH2) is a material with potential applications in laser-driven ion sources.
- Understanding proton emission characteristics is crucial for developing advanced radiation therapies.
Purpose of the Study:
- To investigate proton emission from TiH2 targets irradiated by a Nd:YAG laser.
- To evaluate the potential of TiH2-based sources for ultra-high-dose-rate applications like FLASH-therapy.
Main Methods:
- Irradiation of TiH2 targets in vacuum using a 6-ns, 1064-nm Nd:YAG laser.
- Time-of-flight measurements using a Faraday cup and electrostatic ion analyzer to detect proton emission.
- Systematic scans of laser pulse energy and repeated shots (up to 1000).
Main Results:
- Distinct proton peaks were observed at high pulse energies, with yields around 10^9 protons per shot.
- Integrated proton number remained constant over 1000 shots, despite decreasing peak amplitude.
- Plasma expansion characteristics suggest surface ablation and bulk hydrogen replenishment.
Conclusions:
- TiH2-based laser ion sources demonstrate sustained proton output suitable for high-repetition-rate applications.
- The observed characteristics support TiH2 as a practical candidate for FLASH-therapy research and injector development.
- Direct plasma injection scaling indicates high peak currents and short pulse durations, meeting ultra-high-dose-rate criteria.

