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Correlating Quality of Life with Point-of-Care Intestinal Ultrasound in Inflammatory Bowel Disease (CUALITY Study)
V Parra Izquierdo1,2,3,4, K Ernest Suarez5, M Argollo6
1KU Leuven Department of Chronic Diseases and Metabolism, Translational Research Center for Gastrointestinal Disorders TARGID, Leuven, Belgium.
Background:
Inflammatory bowel disease (IBD) impacts patients' quality of life (QoL), and hence, there is a need to assess this through patient-reported outcomes (PRO). Intestinal ultrasound (IUS) is a non-invasive tool for monitoring IBD activity, but little is known about its correlation with PRO. This study explored the cross-sectional relationship between PRO, assessed by the IBD Questionnaire-32 (IBDQ-32), and IUS parameters in patients with ulcerative colitis (UC).
Methods:
This prospective study included 37 Colombian patients with UC. IUS parameters such as bowel wall thickness (BWT), colour Doppler signal (CDS), and mesenteric fat hypertrophy were assessed, followed by IBDQ-32 completion. Two IUS-experienced gastroenterologists, blinded to the IBDQ- 32, performed the assessments.
Results:
In UC, lower IBDQ-32 scores were significantly correlated with increased BWT (p=0.050), presence of CDS (p=0.022), higher Limberg score (p=0.032), and mesenteric fat hypertrophy (p=0.040). The gastrointestinal and systemic symptom dimensions of the IBDQ-32 showed significant correlations with both BWT (p=0.013 and p=0.013) and CDS (p=0.002 and p=0.003), respectively.
Conclusions:
In UC, IUS parameters are significantly correlated with quality of life, reinforcing the value of IUS as a point-of-care tool.
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