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Fabrication and Biosensing Application of SiO2-TiO2 Hybrid Inverse Opal Fabry-Pérot Layers
Bo Zhang1, Xiaoling Zheng1, Liming Liu1
1State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
Analytical Chemistry
|January 6, 2026
Summary
We developed a novel SiO2-TiO2 hybrid inverse opal biosensor for real-time lipid degradation monitoring. This system uses optical interference fringes to track lipid and lipase digestion with high sensitivity.
Area of Science:
- Materials Science
- Nanotechnology
- Biotechnology
Background:
- Developing advanced biosensors is crucial for real-time monitoring of biomolecular processes.
- Optical interferometry offers label-free detection methods for biological samples.
Purpose of the Study:
- To fabricate SiO2-TiO2 hybrid inverse opal Fabry-Pérot layers for monitoring lipid degradation.
- To create a sensitive biosensing platform for real-time analysis of lipid and lipase digestion.
Main Methods:
- Sol-gel cogrowth strategy to create ordered SiO2-TiO2 hybrid inverse opal structures.
- Optimization of nanosphere concentration for precise film thickness control.
- Integration with an ordered porous layer interferometry (OPLI) platform for biosensing.
Main Results:
- Achieved tunable film thickness (nm to µm) and refractive index (RI) via SiO2-TiO2 ratio.
- Demonstrated high optical interference contrast and RI sensitivity of the fabricated films.
- Developed a biosensor capable of real-time monitoring of lipid and lipase digestion with a wide linear range (5-2000 U/L).
Conclusions:
- The developed SiO2-TiO2 hybrid inverse opal biosensor enables dynamic monitoring of lipid degradation.
- The OPLI-integrated system offers a sensitive and versatile platform for studying liquid-phase biomolecular interactions.
- This technology holds potential for clinical diagnostics and pharmaceutical research applications.
