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Updated: Jan 13, 2026

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Simultaneous detection of elements and molecules using laser ablation-ICP-MS/MS.

Takafumi Hirata1, Chihaya Kinoshita2,3

  • 1Geochemical Research Center, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. hrt1@eqchem.s.u-tokyo.ac.jp.

Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry
|January 6, 2026
PubMed
Summary

Laser ablation inductively coupled plasma tandem mass spectrometry (LA-ICP-MS/MS) rapidly detects elements and molecules in coffee beans. Cationization with silver ions (Ag+) proved most effective for analyzing volatile organic compounds (VOCs).

Keywords:
CationisationDetection of elements and moleculesICP-MS/MSIon reactionLaser ablation

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Area of Science:

  • Analytical Chemistry
  • Materials Science
  • Food Science

Background:

  • Elemental and molecular composition analysis of solid materials is crucial for quality control and understanding material properties.
  • Traditional methods for analyzing both elements and molecules in solid samples often require separate techniques, increasing analysis time and complexity.

Purpose of the Study:

  • To investigate the capability of single ICP-MS/MS coupled with laser ablation for simultaneous elemental and molecular detection in coffee beans.
  • To explore and optimize ionization strategies for volatile organic compounds (VOCs) released from coffee beans using laser-induced thermal desorption.

Main Methods:

  • Utilized laser ablation inductively coupled plasma tandem mass spectrometry (LA-ICP-MS/MS) for direct analysis of solid coffee bean samples.
  • Investigated elemental detection via direct ionization in the ICP and molecular detection of VOCs using collision/reaction cell (CRC) technology.
  • Compared two VOC ionization methods: ion reaction with Argon ions (Ar+) and cationization with Lithium (Li+), Sodium (Na+), and Silver (Ag+) ions.

Main Results:

  • Successfully detected elements (Mg, Ca, Co) and VOCs (butene, propanal, furan, etc.) in coffee beans following laser ablation.
  • Cationization with silver ions (Ag+) demonstrated superior performance for VOC ionization, achieving lower fragmentation and higher adduct production efficiencies compared to Ar+ ion reaction.
  • The LA-ICP-MS/MS technique provided rapid and simultaneous detection of both elemental and molecular species.

Conclusions:

  • LA-ICP-MS/MS is a versatile and rapid analytical technique for the simultaneous detection of elements and molecules in solid matrices like coffee beans.
  • Cationization, particularly with Ag+, offers an effective approach for ionizing VOCs released from solid samples in LA-ICP-MS/MS.
  • This method holds significant potential for applications in food analysis, materials characterization, and other fields requiring comprehensive sample analysis.