A simple linear sweep voltammetric method for the detection of glucose using an Ag-Au/MWCNT nanocomposite-modified...

Efficient monitoring of blood glucose levels is crucial for diabetes management, yet many existing sensors involve complex fabrication steps or unstable enzymatic components. In this study, a non-enzymatic glucose sensor was fabricated using a simple one-step electrodeposition method using a bimetallic Ag-Au/MWCNT nanocomposite-modified glassy carbon electrode (GCE). Despite the simplicity of the process, SEM-EDS and XRD analyses confirmed the successful and uniform formation of Ag-Au nanoparticles on the MWCNT surface. The resulting Ag-Au/MWCNT/GCE exhibited excellent electrocatalytic activity, a large electroactive surface area, and superior selectivity, stability, and reproducibility. Optimization obtained that the best performance was achieved with an Ag:Au ratio of 1:2 (0.2 mM Ag and 0.4 mM Au) after five electrodeposition cycles. Under these optimized conditions, the sensor showed a linear response to glucose concentrations from 0.1 to 10 mM, with an R² value of 0.9983 and a detection limit of 0.158 mM. These results highlight the potential of this straightforward electrodeposition strategy for developing simple yet efficient enzyme-free glucose sensors.