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Curcumin Alleviates Gastric Precancerous Lesions by Modulating YAP/TEAD Signaling Pathway
Jinhao Zeng1,2, Shangbin Lv3, Maoyuan Zhao4
1TCM Prevention and Treatment of Metabolic and Chronic Diseases Key Laboratory of Sichuan Province, Chengdu, China.
Phytotherapy Research : PTR
|January 6, 2026
Summary
Curcumin (CUR) can prevent and treat gastric precancerous lesions (GPL) by reducing inflammation and modulating the YAP/TEAD pathway. This natural compound shows promise in alleviating gastric mucosal damage.
Area of Science:
- Gastroenterology
- Molecular Biology
- Pharmacology
Background:
- Gastric precancerous lesions (GPL) pose a significant health risk, and effective treatments are limited.
- Curcumin (CUR), derived from Curcuma longa Linn., is known for its bioactivities but its role in GPL is unexplored.
- Understanding the mechanisms of CUR in GPL is crucial for developing novel therapeutic strategies.
Purpose of the Study:
- To investigate the therapeutic effects of Curcumin (CUR) on gastric precancerous lesions (GPL).
- To elucidate the underlying molecular mechanisms of CUR action in both in vitro and in vivo models of GPL.
- To evaluate CUR's impact on gastric inflammation and cellular proliferation.
Main Methods:
- An N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced rat model of GPL was utilized.
- A human gastric epithelial cell (MC cell) malignant transformation model was employed for in vitro studies.
- Biochemical assays, immunohistochemistry, and analysis of cytokine levels were performed.
Main Results:
- CUR treatment reversed intestinal metaplasia and dysplasia in GPL rats.
- CUR modulated levels of gastrin 17, pepsinogen I (PG I), prostaglandin E2 (PGE2), and various interleukins (ILs) and tumor necrosis factor α (TNF-α).
- CUR downregulated YAP1 and TEAD1 expression while upregulating p-YAP1 and apoptosis-related proteins, indicating modulation of the Hippo signaling pathway.
Conclusions:
- Curcumin (CUR) effectively alleviates gastric mucosal inflammation and prevents the occurrence and progression of gastric precancerous lesions (GPL).
- CUR's therapeutic potential may be mediated through the modulation of the YAP/TEAD axis within the Hippo signaling pathway.
- These findings highlight CUR as a promising agent for the prevention and treatment of GPL.
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