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Updated: Jan 13, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
Published on: November 11, 2016
Biological clocks keep a watch on mitosis
Colin Richard Gliech1, Andrew Jon Holland2
1Division of Rheumatology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
None:
Accurate chromosome segregation is vital for organismal development and homeostasis, with errors in this process strongly associated with tumourigenesis. A network of safeguard clocks preserves mitotic fidelity by detecting and eliminating cells dividing outside the stereotyped duration of successful mitosis. This Perspective examines recent advances in our understanding of mitotic timing mechanisms, presents emerging evidence for novel mitotic clocks and proposes a conceptual framework for how cells integrate temporal cues to preserve genomic integrity.
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