[Chronic skin damage from UV radiation]

Ultraviolet (UV) radiation is the primary risk factor for the development of both melanocytic and nonmelanocytic skin cancer. In particular, UVA and UVB radiation are the main cause for DNA damage and inflammatory responses that promote tumor formation, thus, contributing to the development of basal cell carcinoma, squamous cell carcinoma, and melanoma. Furthermore, repeated exposure to UV light accelerates premature skin aging (photoaging), resulting in visible structural changes. In recent years, the incidence of skin cancer in Germany has been steadily increasing. Preventive measures, in addition to regular screening examinations, play a crucial role. This includes UV avoidance, consistent use of protective clothing, and the application of appropriate sunscreens. Dermatologists have the crucial responsibility to educate patients about the effects of UV exposure and to promote effective protection strategies. In this regard, personalized approaches to sun protection will continue to play an increasingly important role. Future UV protection concepts will be tailored to take into consideration individual factors such as skin type and genetic predisposition, as well as exposomal influences. These factors would then be further evaluated using artificial intelligence to enable truly personalized sun protection. This personalized approach aligns with the broader trend toward precision medicine but also presents scientific, ethical, and practical challenges. Responsible implementation will therefore be essential to ensure these innovations are applied safely and equitably.