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Minimal Clinically Important Difference After Triamcinolone Acetonide Injection for Knee Osteoarthritis.

Jesse M Galina1, Meghan L Morley2, Sibtain Mustafa2

  • 1Department of Orthopaedic Surgery, Maimonides Medical Center, Brooklyn, New York; and.

Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine
|January 7, 2026
PubMed
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Minimal clinically important difference (MCID) for triamcinolone acetonide (TA) injections in knee osteoarthritis (OA) was established. Early pain improvement within one month is key, as lack of it predicts repeat injections.

Area of Science:

  • Orthopedics
  • Rheumatology
  • Pharmacology

Background:

  • Knee osteoarthritis (OA) significantly impacts patient quality of life.
  • Intra-articular corticosteroid injections, such as triamcinolone acetonide (TA), are common treatments for OA.
  • Defining the minimal clinically important difference (MCID) is crucial for evaluating treatment efficacy.

Purpose of the Study:

  • To define the MCID for TA injections in knee OA patients.
  • To assess if MCID values change over a 6-month period.
  • To determine the proportion of patients achieving MCID monthly post-injection.

Main Methods:

  • Retrospective case series of 277 patients with knee OA receiving TA injections.
  • Knee Injury and Osteoarthritis Outcome Score (KOOS) was administered pre-injection and monthly for 6 months.
Keywords:
corticosteroidinjectionkneeminimal clinically important differenceosteoarthritistreatment

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  • MCID was calculated as 0.5 standard deviations from preinjection KOOS scores.

    • Main Results:

    • MCID values varied across KOOS subscales (7.98-12.35).
    • The proportion of patients achieving MCID for pain ranged from 36.2% to 50.5% across the 6-month follow-up.
    • Patients not achieving MCID for pain by 1 month had a 2.19 times higher odds of receiving a repeat injection within 6 months.

    Conclusions:

    • Distribution-based MCID values for KOOS subscales in knee OA patients receiving TA injections were established.
    • Significant pain improvement is expected within the first month, with diminishing effects over time.
    • Lack of early pain improvement is a predictor for repeat injections, highlighting the importance of follow-up assessments.