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Neuroinflammation-driven glymphatic dysfunction: implications for disease progression and drug-based modulation.
Syeda Tayyaba Batool1, Umair Ali2, Muhammad Ijaz Khan2
1Department of Medicine, Azad Jammu and Kashmir Medical College, Muzaffrabad, Pakistan.
The glymphatic system clears waste in the brain, but its dysfunction, marked by inflammation and impaired fluid exchange, accelerates neurodegenerative diseases. Therapeutic strategies targeting glial metabolism and vascular health may restore glymphatic function.
Area of Science:
- Neuroscience
- Immunology
- Cellular Biology
Background:
- The glymphatic system is crucial for central nervous system waste removal.
- Impairment of the glymphatic system is associated with neuroinflammation and disease progression.
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