Psoriasis and atrial fibrillation: Exploring the intersection

Area of Science:

• Cardiology
• Dermatology
• Immunology

Background:

• Psoriasis is a chronic inflammatory disease linked to increased cardiovascular risk.
• Systemic inflammation in psoriasis involves cytokines like IL-6, IL-17, and TNF-alpha.
• These cytokines may contribute to atrial remodeling and dysfunction, increasing AF susceptibility.

Purpose of the Study:

• To explore the connection between psoriasis and atrial fibrillation (AF).
• To review shared inflammatory mechanisms, clinical implications, and research gaps.
• To highlight the need for integrated care for psoriasis patients at risk of AF.

Main Methods:

• Review of existing epidemiological and biological data.
• Synthesis of information on inflammatory mediators and their effects on the atria.
• Analysis of observational studies and identification of research limitations.

Main Results:

• Psoriasis is associated with elevated pro-inflammatory cytokines.
• These cytokines can lead to atrial remodeling, fibrosis, and conduction abnormalities.
• Severe psoriasis correlates with increased atrial dysfunction and AF risk.

Conclusions:

• Shared inflammatory mechanisms link psoriasis and AF.
• Observational studies suggest a causal link, but further research is needed.
• Integrated dermatological and cardiology care is essential for managing AF risk in psoriasis patients.