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Articles linked to this work by shared authors, journal, and citation graph.

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Related Experiment Video

Updated: Jan 13, 2026

An In Vivo Murine Sciatic Nerve Model of Perineural Invasion
09:55

An In Vivo Murine Sciatic Nerve Model of Perineural Invasion

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Intraoperative Molecular Imaging Can Detect Large Nerve Perineural Invasion: A Case Report.

Carleigh R Burns1, Aviva S Mattingly1, Kim Ely2

  • 1Department of Otolaryngology - Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Head & Neck
|January 7, 2026
PubMed
Summary

Intraoperative fluorescence imaging using Panitumumab-IRDye800 successfully identified subclinical perineural invasion (PNI) in head and neck squamous cell carcinoma (SCC), aiding in complete tumor resection and improving patient outcomes.

Area of Science:

  • Oncology
  • Surgical Innovation

Background:

  • Perineural invasion (PNI) in head and neck squamous cell carcinoma (SCC) is associated with poorer survival.
  • Current diagnosis of PNI necessitates surgical resection and microscopic examination.
Keywords:
Panitumumab‐IRDye800fluorescence‐guided surgeryhead and neck squamous cell carcinomaintraoperative visualizationperineural invasion

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