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Updated: Jan 13, 2026

Analysis of the Lipid Composition of Mycobacteria by Thin Layer Chromatography
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Measuring Membrane Fluidity in Live Mycobacteria Reveals Subcellular Lateral Variation And Pole-Selective Responses

Isabel Sakarin, Cyrus Clabeaux, Lia A Parkin

    ACS Infectious Diseases
    |January 7, 2026
    PubMed
    Summary

    Mycobacterial cell envelope fluidity, crucial for antibiotic tolerance, was measured directly in live cells. Researchers found poles are more fluid than sidewalls, and this fluidity impacts antibiotic susceptibility.

    Keywords:
    antibiotic susceptibilityenvironmentally sensitive fluorophoresmembrane fluiditymembrane heterogeneitymycobacteriamycomembrane

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