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Related Concept Videos

Functional Classification of Joints01:09

Functional Classification of Joints

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Functional Classification of Joints
The functional classification of joints is determined by the amount of mobility between the adjacent bones. Joints are functionally classified as a synarthrosis or immobile joint, an amphiarthrosis or slightly moveable joint, or as a diarthrosis, a freely moveable joint. Fibrous and cartilaginous joints can be functionally classified as either synarthroses  or amphiarthroses, whereas all synovial joints are classified as diarthroses.
Synarthrosis
An...
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Updated: Jan 13, 2026

Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology
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Decoding Temporomandibular Disorders: Identifying Stage-Specific and Functional Patterns in the Articular Disc.

Pascal Eber1,2, Ana M P Baggio1,3, Yannick M Sillmann1,4

  • 1Division of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Harvard School of Dental Medicine, Boston, MA, USA.

Stem Cell Reviews and Reports
|January 7, 2026
PubMed
Summary
This summary is machine-generated.

Identifying biomarkers in the temporomandibular joint (TMJ) articular disc aids understanding of TMJ disorders (TMD). Classification of these biomarkers aids early detection and personalized treatment strategies for TMD.

Keywords:
Artificial intelligence, biasBiomarkerDisease progressionTemporomandibular joint discTemporomandibular joint disorders

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Area of Science:

  • Biomarkers
  • Immunohistochemistry
  • Temporomandibular Joint Disorders (TMD)

Background:

  • Temporomandibular disorders (TMD) affect ~30% of the population, with unclear pathogenesis.
  • Disc displacement and degeneration are linked to biomechanical dysfunction.
  • Articular disc biomarkers are key to understanding TMD mechanisms and improving diagnostics/therapeutics.

Purpose of the Study:

  • Review immunohistochemical biomarkers in the TMJ articular disc.
  • Focus on internal derangement and disc displacement.
  • Correlate biomarkers with clinical, radiological, and histological findings for functional and stage-specific relevance.

Main Methods:

  • Systematic literature search of databases and journals.
  • Included studies used immunohistochemistry and control groups.
  • Analyzed biomarker patterns, clinical, radiological, histological findings, and demographics per PRISMA guidelines.

Main Results:

  • Included 511 patients (579 samples) and 132 controls (158 samples).
  • Identified 24 biomarkers involved in inflammation, ECM remodeling, and degeneration.
  • Classified biomarkers by function and stage for early detection, staging, and personalized treatment.

Conclusions:

  • Disc biopsy provides insights into TMD progression from displacement to degeneration.
  • Clinical utility of disc biopsy is limited by invasiveness, ethics, and lack of standardized protocols.
  • Further research needed for validated biomarker profiles and reliable study designs.