[Early prevention and control of ICU-acquired weakness: intervention strategies based on the time window]

ICU-acquired weakness (ICU-AW), as a common complication in the intensive care unit (ICU), has received increasing attention from clinicians due to its potential to cause severe functional impairments in survivors. Early research primarily focused on the definition, diagnosis, pathophysiology, and risk factors of ICU-AW, while systematic studies on stepwise interventions aligned with disease progression remain scarce. Current guidelines merely advocate for early mobilization, without specifying the timing or content of interventions. This paper reviews relevant domestic and international studies to summarize the time-window-based pathogenesis and intervention measures of ICU-AW, aiming to identify time-window-based prevention and control strategies for ICU-AW and optimize the implementation pathway based on the characteristics of ICU resource allocation in China.