[Expert Consensus on the Clinical Application of Sodium Cantharidinate and Vitamin B6 Injection]

Cancer prevention and control in China face severe challenges. Although targeted therapy and immunotherapy have made remarkable progress, chemotherapy remains a cornerstone of comprehensive cancer treatment, and its toxic side effects pose a significant challenge in clinical practice. As a compound formulation exhibiting both antitumor and toxicity-reducing effects, Sodium cantharidinate and vitamin B6 injection has been utilized in clinical practice in China for over two decades. However, standardized guidelines for its application remain lacking in routine clinical use. To address this gap, the Lung Cancer Specialty Committee of Chinese Elderly Health Care Association organized a panel of experts to develop this consensus document, drawing on current evidence-based data and accumulated clinical experience. This consensus provides a systematic elaboration of the preparation's pharmacological mechanisms and pharmacokinetic profiles, and offers specific recommendations for its clinical application across various malignancies, including lung cancer and hepatocellular carcinoma. The primary objective of this consensus is to establish standardized guidance for clinicians regarding the appropriate use of Sodium cantharidinate and vitamin B6 injection, thereby promoting its rational application and ultimately enhancing treatment efficacy and quality of life for cancer patients.
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