[Research Progress of TNMB Staging in Lung Cancer]

Lung cancer is the malignant tumor with the highest incidence and mortality in China, and accurate clinical staging is crucial for judging its prognosis and formulating treatment strategies. Currently, the internationally recognized tumor-nodule-metastasis (TNM) staging system centers on tumor anatomical characteristics but struggles to reflect the biological essence of tumors. Based on the TNM staging, the TNM-blood (TNMB) staging incorporates blood molecular biomarkers to achieve multi-dimensional assessment of anatomical and biological characteristics. Initially applied to cutaneous T-cell lymphoma, it has gradually expanded to the field of lung cancer in recent years. This review summarizes the existing research and applications of TNMB staging in lung cancer, comparatively analyzes the differences between TNMB and the traditional TNM staging in terms of staging basis, evaluation dimensions and clinical efficacy, and further summarizes the existing types of molecular biomarkers related to B staging as well as those expected to be included in B staging.
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