[The Research Progress of Second Cancer Onset in Myeloproliferative Neoplasms --Review]

Patients with myeloproliferative neoplasms (MPNs) are at risk of developing solid tumors. Although the connection between MPN and solid tumors has been widely discussed, the cause remains to be explored. Some studies show that the MPN is considered to trigger a second cancer, but others suggest both diseases seem to share the same origin. In recent years, more and more studies have found that genetic susceptibility, drugs, chronic inflammation, immune function abnormalities and clonal hematopoiesis of indeterminate potential are related to the development of second cancers. In this review, we try to summarize the new advances of biological characteristics and pathogenesis of second cancers in MPNs.