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Acute and Chronic Presentation of Melioidosis: 18 F-FDG PET/CT Case Series
Harini Koorma1, Mohan Roop Jayanthi1, Haripriya Reddy Challa2
1Department of Nuclear Medicine and PET-CT, AIG Hospitals, Hyderabad, Telangana, India.
Abstract:
Melioidosis is an infectious disease that is caused by a gram-negative bacillus, Burkholderia pseudomallei , which has been designated as a category B bioterrorism agent by the U.S. Centers for Disease Control and Prevention. Melioidosis manifests as a multi-system disorder. The effectiveness of 18 F-FDG PET/CT (18-fluorine-fluorodeoxyglucose positron emission tomography-computed tomography) in diagnosing or managing melioidosis is currently uncertain or not well-established. 18 F-FDG PET/CT is a useful tool in detecting the location and extent of abscess formation, assessing the organs involved, and detecting occult foci of infection, due to the multifocal nature of the disease. Herein, we present cases of two patients referred for a whole-body 18 F-FDG PET/CT scan with a history of pyrexia of unknown origin.
Insights
Melioidosis, a serious infection caused by Burkholderia pseudomallei, can be challenging to diagnose. This study explores the utility of 18-fluorine-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET/CT) in identifying this multi-system disease.
Area of Science:
- Infectious Diseases
- Medical Imaging
- Nuclear Medicine
Background:
- Melioidosis is a severe, multi-system infectious disease caused by Burkholderia pseudomallei, a Category B bioterrorism agent.
- The diagnostic and management utility of 18-fluorine-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET/CT) for melioidosis is not well-established.
- Melioidosis often presents as a multifocal infection, making detection of all affected sites crucial.
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