Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

542
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
542
Bipolar Disorder01:30

Bipolar Disorder

612
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
612
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

460
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
460
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

802
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
802
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

797
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
797
Drug Therapy01:28

Drug Therapy

239
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
239

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Functional and genomic insights into probiotic lactic acid bacteria isolated from the gastrointestinal microbiota of domestic rabbits (Oryctolagus cuniculus).

BMC microbiology·2026
Same author

Internalized stigma in patients with severe mental illness (SMI): A cross-sectional study from Northwestern India.

Indian journal of psychiatry·2026
Same author

The lure of 'Healthier Smoke': Comparative physical, chemical, and oxidative potential characterization of emissions from herbal and tobacco cigarettes.

Journal of hazardous materials·2026
Same author

Bupropion-induced early-onset urticaria.

BMJ case reports·2026
Same author

Sleep quality and its determinants among pregnant women in Northwest India: A cross-sectional study.

Indian journal of psychiatry·2026
Same author

Adult SLD Certification in Real-world Settings: Too Late or Still Valid.

Indian journal of psychological medicine·2026

Related Experiment Video

Updated: Jan 13, 2026

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

1.2K

Untangling late-onset first-episode mania: A case series.

Harsh Khandelwal1, Sanyam Tyagi1, Harmanpreet Kaur2

  • 1Department of Psychiatry, All India Institute of Medical Science, Jodhpur, Rajasthan, India.

Indian Journal of Psychiatry
|January 8, 2026
PubMed
Summary

Late-onset bipolar disorder presents diagnostic challenges in the elderly. This case series highlights treatment responses and comorbidities in four elderly patients with first-episode mania.

Keywords:
Elderly first episode manialate onset bipolarmanagement

More Related Videos

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

11.0K
Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
07:35

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale

Published on: July 8, 2025

1.1K

Related Experiment Videos

Last Updated: Jan 13, 2026

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

1.2K
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

11.0K
Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
07:35

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale

Published on: July 8, 2025

1.1K

Area of Science:

  • Geriatric Psychiatry
  • Neuropsychiatry
  • Bipolar Disorder Research

Background:

  • Late-onset bipolar disorder (LOB) poses diagnostic and management difficulties.
  • Symptoms can overlap with neurocognitive disorders and medical conditions in older adults.
  • Age-related physiological changes complicate LOB diagnosis and treatment.

Purpose of the Study:

  • To present clinical trajectories of elderly patients with first-episode mania.
  • To analyze comorbidities and treatment responses in this population.
  • To underscore the need for further research in LOB management.

Main Methods:

  • Case series reporting on four elderly patients with first-episode mania.
  • Review of clinical presentations, comorbidities, and treatment outcomes.
  • Inclusion of neuroimaging findings (small vessel ischemic changes).

Main Results:

  • Three patients had metabolic comorbidities; two had a family psychiatric history.
  • Neuroimaging suggested a potential vascular contribution in two cases.
  • All patients required inpatient care and responded to mood stabilizers and antipsychotics.

Conclusions:

  • Elderly patients with first-episode mania require specialized care.
  • Mood stabilizers and antipsychotics appear effective in this cohort.
  • Further research is essential to refine management strategies for LOB.