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Related Experiment Video

Updated: Jan 13, 2026

Ferric Chloride-induced Thrombosis Mouse Model on Carotid Artery and Mesentery Vessel
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Antithrombotic Therapy on Antithrombin Resistance in a Mouse Model.

Nobuaki Suzuki1, Atsuo Suzuki2, Shogo Tamura3

  • 1Department of Transfusion Medicine (Nobuaki Suzuki, T.M.), Nagoya University Hospital, Japan.

Arteriosclerosis, Thrombosis, and Vascular Biology
|January 8, 2026
PubMed
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Antithrombin resistance (ATR) causes a tendency for blood clots due to abnormal prothrombin (FII). Mouse models show that anticoagulants targeting thrombin (FIIa) are effective treatments for ATR.

Area of Science:

  • Hematology
  • Thrombosis Research
  • Pharmacology

Background:

  • Antithrombin resistance (ATR) is a genetic condition leading to thrombotic predisposition.
  • It stems from abnormal prothrombin (FII) with reduced binding affinity to antithrombin (AT).
  • Limited data exist on anticoagulant efficacy in ATR patients.

Purpose of the Study:

  • To develop and validate mouse models for studying ATR.
  • To investigate the efficacy of various anticoagulants in ATR models.
  • To understand the antithrombotic effects of anticoagulants targeting thrombin (FIIa).

Main Methods:

  • Generated knock-in mice expressing human FII R596L equivalent (FII R593L).
  • Confirmed ATR characteristics via blood coagulation analysis.
Keywords:
anticoagulantsantithrombinmice transgenicprothrombinthrombin-antithrombin complex

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  • Assessed thrombotic tendency using an inferior vena cava stenosis model.
  • Evaluated anticoagulants: unfractionated heparin, LMWH, pentasaccharide, and DOACs.

    • Main Results:

    • ATR model mice (R593L Homo/Hetero) showed reduced FII levels but confirmed ATR properties.
    • Significantly increased thrombus formation was observed in ATR mice compared to wild-type.
    • Anticoagulants with anti-FIIa activity demonstrated higher efficacy in R593L mice.

    Conclusions:

    • FII R593L knock-in mice accurately model ATR and exhibit a strong thrombotic tendency.
    • Anticoagulants targeting FIIa are highly effective in managing ATR-related thrombosis.