Related Experiment Video
Updated: Jan 13, 2026
Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
Published on: April 19, 2024
Anti-Complementary Constituents From Artemisia vestita Alleviate H1N1-Induced Acute Lung Injury
Xue Liao1,2, Ji-Bin Zou2, Huai-Chang Zhu2
1School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Abstract:
Artemisia vestita is a traditional Tibetan folk medicine. Bioactivity-guided fractionation revealed that the petroleum ether fraction of A. vestita possessed potent anti-complementary activity (CH50: 0.016 ± 0.006 mg/mL), demonstrating therapeutic efficacy against H1N1-induced viral pneumonia in murine models. Subsequent phytochemical analysis of this bioactive extract using silica gel chromatography coupled with semi-preparative high-performance liquid chromatography yielded 14 compounds, including three new monoterpenes (1-3) and one coumarin (13) with relatively high abundance. Notably, studies on the activity of the isolated compounds revealed that the coumarin (scopoletin) exhibits dominant anti-complementary activity and provides significant protective effects against H1N1-induced viral pneumonia in mice. This study provides insights into the development and utilization of A. vestita and scopoletin.
Related Concept Videos
01:23Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
01:19Antiasthma Drugs: Leukotriene Modifiers
Leukotriene modifiers work through two distinct mechanisms:
01:16Drugs Used in Upper Respiratory Disorders: Overview
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
01:20Antiasthma Drugs: Muscarinic Receptor Antagonists
Antimuscarinic agents compete with ACh for the same binding site on the muscarinic receptors. By binding to these receptors, they inhibit the downstream effects of ACh and block the parasympathetic...
01:30Adrenergic Agonists: Therapeutic Uses
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...