ISHLT Consensus Statement on Short Telomere Syndrome and Lung Transplantation

Area of Science:

• Pulmonology
• Genetics
• Transplant Surgery

Background:

• Shortened telomeres are increasingly linked to interstitial lung disease (ILD) progression.
• Short telomere syndrome (STS) is associated with extrapulmonary conditions affecting lung transplant candidacy and outcomes.
• Current evaluation and management strategies for STS in ILD patients have significant gaps.

Purpose of the Study:

• To address the diagnostic and management gaps in patients with short telomere syndrome (STS) and interstitial lung disease (ILD).
• To provide expert consensus and literature-based recommendations for the multidisciplinary care of STS patients.
• To highlight the underdiagnosis of STS as a contributor to ILD and its complexities in lung transplantation.

Main Methods:

• Consensus statement development by an international Writing Committee.
• Comprehensive review of current literature on STS and ILD.
• Expert opinion and consensus-building on evaluation and management strategies.

Main Results:

• STS is an underdiagnosed condition contributing to ILD.
• STS presence complicates lung transplant candidacy and post-transplant management.
• Dedicated, multidisciplinary attention is required for STS patients.

Conclusions:

• There is a critical need for improved recognition and management of STS in ILD.
• Addressing STS complexities is essential for optimizing lung transplant outcomes.
• This consensus statement provides a framework for expert-led, evidence-based care.